Volume 29, Issue 4, 2020
DOI: 10.24205/03276716.2020.887
Clinical Therapeutic Effects of Amoxicillin/Clavulanate Potassium Administered by Different Methods on Recurrent Lower Respiratory Tract Infection in Children
Abstract
Objective: To evaluate the clinical therapeutic effects of amoxicillin/clavulanate potassium administered by different methods on recurrent lower respiratory tract infection in children.
Methods: A total of 110 children admitted to Department of Pediatrics, Suixi Hospital and diagnosed as recurrent lower respiratory tract infection from January 2017 to January 2019 were selected as the subjects. They were equally divided into control group and observation group using a random number table. Amoxicillin/clavulanate potassium was administered through routine intravenous infusion and sequential therapy for control group and observation group, respectively. The clinical efficacy, T-lymphocyte subsets, immunoglobulin (Ig) level and incidence rate of adverse reactions were compared between the two groups.
Results: The clinical overall response rate was higher in observation group than that in control group (94.54% vs. 78.18%) (χ2=6.253, P=0.012). Cluster of differentiation 4 (CD4) +/CD8+, CD4+ and CD3+ were higher at the end of treatment than those before treatment in the two groups, but CD8+ was lower than that before treatment. At the end of treatment, CD4+/CD8+, CD4+ and CD3+ increased in observation group compared with those in control group, while CD8+ decreased compared with that in control group (P<0.05). Serum IgA, IgM and IgG were higher at the end of treatment than those before treatment in the two groups, but C-reactive protein (CRP) was lower than that before treatment (P<0.05). At the end of treatment, observation group had significantly raised serum IgA, IgM and IgG as well as significantly reduced CRP in comparison with those of control group (P<0.05). The incidence rate of adverse reactions was significantly lower in observation group than that in control group (7.27% vs. 27.27%) (χ2=7.698, P=0.006).
Conclusion: Sequential therapy using amoxicillin/clavulanate potassium for recurrent lower respiratory tract infection in children can correct immune dysfunction and reduce adverse reactions with obvious efficacy and high safety.
Keywords
amoxicillin; clavulanate potassium; sequential therapy; children; recurrent lower respiratory tract infection; clinical therapeutic effect; safety