Volume 33, Issue 1, 2024
DOI: 10.53555/03276716.2024.07
Harnessing Amygdalin In Integrative Medicine: Novel Insights For Endocrine Disorders
Abstract
Amygdalin, often known as vitamin B17, is a cyanogenic glycoside that is mostly present in almond, cherry, and apricot seeds. The FDA has limited its usage in the United States because of its metabolism into hydrogen cyanide, which offers serious health hazards, even though it has historically been used for its alleged anticancer properties. Amygdalin and its derivatives, such as prunasin and mandelonitrile, may have pharmacological qualities, such as antiinflammatory and antioxidant benefits, notwithstanding these reservations. The complex pathophysiology of Polycystic Ovary Syndrome (PCOS), a common endocrine disorder characterized by hyperandrogenism and prolonged anovulation, includes inflammation as a major component in addition to hormonal and metabolic dysfunctions. Common in individuals, insulin resistance is linked to elevated levels of inflammatory markers such TNF-?, CRP, and IL-6. The therapy of PCOS may benefit from the use of interleukin-10 (IL-10), an antiinflammatory cytokine. Due to insulin resistance and other metabolic abnormalities linked to the disorder, PCOS and type 2 diabetes are significantly correlated. This mechanism involves the MAPK/ERK1/2 signaling pathway in addition to the crucial function of GLUT transporters in glucose metabolism. The possibility of cyanide poisoning raises concerns about amygdalin's safety, even though it may have therapeutic advantages for oxidative stress and reproductive health. To investigate its potential advantages while maintaining patient safety, more study is required.
Keywords
Amygdalin, Laetrile, Vitamin B17, Cyanide, Anticancer properties, Polycystic Ovary Syndrome (PCOS), Insulin resistance, Chronic inflammation, Type 2 diabetes, Antioxidant properties